Browsing by Author "Kubaychuk, O"

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Functional moments estimators analysis by the Monte-Carlo method for model of mixture with varying concentrations
(Journal of Advances in Mathematics (JAM)., 2018) Kubaychuk, O
The functional moments estimation by the sample from the mixture with varying concentrations is studied. The problem of efficiency the simple linear estimator with fixed weight against the adaptive or improved estimators with random weight is considered. By the Monte-Carlo method it is shown that simple linear estimator is better for small sample sizes, but for large samples the adaptive and improved estimators are more efficient.
Hypoxic regulation of MYBL1, MEST, TCF3, TCF8, GTF2B, GTF2F2 and SNAI2 genes expression in U87 glioma cells upon ire1 inhibition
(Ukr. Biochem. J., 2016) Kubaychuk, O
We investigated the impact of IRE1/ERN1 (inositol requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) knockdown on hypoxic regulation of the expression of a subset of proliferation and migration- related genes in U87 glioma cells. It was shown that hypoxia leads to up-regulation of the expression of MEST and SNAI2, to down-regulation – of MYBL1, TCF8 and GTF2F2 genes at the mRNA level in control glioma cells. At the same time hypoxia does not affect the expression of TCF3 and GTF2B transcription factor genes. In turn, inhibition of IRE1 modifies the effect of hypoxia on the expression of all studied genes, except MYBL1 and GTF2B. For instance, IRE1 knockdown decreases sensitivity to hypoxia of the expression of MEST, TCF8 and SNAI2 genes and increases sensitivity to hypoxia of GTF2F2 expression. At the same time IRE1 inhibition introduces sensitivity to hypoxia of the expression of TCF3 gene in glioma cells. The present study demonstrates the inhibition of IRE1 in glioma cells affects the hypoxic regulation of the expression of genes studied. Hypoxic conditions do not abolish the effect of IRE1 inhibition on the expression of respective genes. To the contrary, in case of SNAI2, GTF2F2 and MEST hypoxic conditions magnify the effect of IRE1 inhibition on the expression of respective genes in glioma cells.
MODELING OF CHAMPIGNON STIPE DRYING PROCESS
(Наукові праці НУХТ., 2015) Kubaychuk, O
The problem of champignons drying has beenn investigated in this article. The optimum temperature for drying is the temperature at which the final product has the best taste and retains the maximal quantity of nutrients. The research was conducted using the method of simultaneous thermal analysis. It was established experimentally that the optimum temperature for the stipes and caps of champignons vary significantly. The models of drying fungi stipes at different fixed temperatures have been developed. The drying process of fungi stipes at optimum temperature has been modeled.
The asymptotic behaviour of threshold-based classification rules in case of three prescribed classes
(Journal of Advances in Mathematics, 2016-06) Kubaychuk, O
We consider the problem of the classification of an object from the observation after its numerical characteristic in case of three prescribed classes. We also study a problem on finding and asymptotic behaviour of threshold-based classification rules constructed from a sample from a mixture with varying concentrations.