Політ. Екологічна безпека, інженерія та технології. 2021

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Browsing Політ. Екологічна безпека, інженерія та технології. 2021 by Subject "beta-lactam antibiotic"

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    Bacteria resistance to beta-lactam antibiotics
    (National Aviation University, 2021-04) Vasilenko, Sofia; Василенко, Софія
    Increasing antibiotic resistance of microorganisms is one of the urgent and unresolved problems in the fight against pathogenic microorganisms. Antibiotic resistance of microorganisms can be true and acquired. True resistance is characterized by the absence of the antibiotic action of the target in microorganisms or the inaccessibility of the target due to the primary low permeability or enzymatic inactivation. Acquired resistance it is the property of individual bacterial strains to maintain viability at those concentrations of antibiotics that suppress the bulk of the microbial population. The formation of resistance in all cases is due to genetics - the acquisition of new genetic information or a change in the level of expression of its own genes. The most common cause of acquired resistance is the widespread use of a particular antibiotic, and the consequence is that previously sensitive strains become resistant. Beta-lactam antibiotics - penicillins, cephalosporins have been used for the longest time in clinical practice, so the problem of resistance to them is the most serious. Let’s consider the most common reasons of antibiotic resistance development: unreasonable appointment of antibacterial drugs (ABD), mistakes in choosing the ABD, errors in the choice of the ABP dosing mode, errors associated with the duration of antibiotic therapy.